I would say yes, but with some caveats. I haven’t read every science fiction book ever written, and therefore do not have the background knowledge with which I could make a surefire claim to Dune’s greatness, but I will do my best to lay out my reasons for loving this book.

Dune won both the Hugo and Nebula awards in 1966 and although book sales were initially tepid, the franchise grew to contain subsequent novels, comic books, board games, video games, and one (admittedly bad) movie. And while I could expound upon the sprawling complexity and detail of Dune’s universe, what makes this franchise special is its unique focus on the human element. Dune, unlike many prominent science fiction franchises, pays little attention to technology. Robots and machines are almost absent from the narrative. The protagonist fights in gladiatorial duels with nothing but a knife and his wits. Space pilots navigate hyperspace using prescient visions imparted by a mystical drug called “spice.” Through a system of eugenics and specialized education, certain bloodlines in the human race have become something more; transhumans capable of reading people’s minds and seeing the future. And while the universe of Dune is huge and complex, the book focuses primarily on the way that this transhuman evolution changes people. The book’s protagonist, Paul Atreides, learns that he is Maud Dib, the fabled savior of a planet and its people. In the process of becoming this fabled hero, Paul gains the ability to see all of space and time. The narrative meditates long on the impact that this change has on Paul. And while an epic space opera plays out in the background as assassination and planetary invasion keep the plot moving forward, the novel is centered around characters struggling to do ‘right’ in a universe where people can become gods. It’s a story about faith and destiny and what those things even mean. It’s a great book, maybe the best science fiction novel ever, and I could not recommend it enough.

https://www.wired.com/2012/12/and-the-winner-is-readers-choice-for-top-10-science-fiction-novel/

And I’m not saying this (^) is proof, but…